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Context matters: T(H)2 polarization resulting from pollen composition and not from protein-intrinsic allergenicity.

J. Allergy Clin. Immunol. 142, 984-987.e6 (2018)
Publishers Version online available 06/2021 Free by publisher as soon as is submitted to ZB.
In contrast to the pollen context, the major allergen Bet v 1 alone is not responsible for Th2 polarization in allergic sensitization. These findings are highly relevant for birch pollen allergy prophylaxis.
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Publication type Article: Journal article
Document type Letter to the Editor
Keywords Allergic Sensitization ; Bet V 1 ; Lps ; Tlr4 ; Th2 Polarization ; Allergenicity ; Allergy Prophylaxis ; Birch Pollen ; Pollen Extract; Allergic Contact-dermatitis; Genome-wide Association; Antigen-presenting Cells; T-cells; Collaborative Cross; Rapid Identification; Molecular-mechanisms; Immune-responses; Dendritic Cells; Transgenic Mice
Reviewing status
Institute(s) Institute for Allergy Research (IAF)
Institute of Environmental Medicine (IEM)