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Conrad, M. ; Kagan, V.E.* ; Bayir, H.* ; Pagnussat, G.C.* ; Head, B.* ; Traber, M.G.* ; Stockwell, B.R.*

Regulation of lipid peroxidation and ferroptosis in diverse species.

Genes Dev. 32, 602-619 (2018)
Verlagsversion DOI
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
Lipid peroxidation is the process by which oxygen combines with lipids to generate lipid hydroperoxides via intermediate formation of peroxyl radicals. Vitamin E and coenzyme Q react with peroxyl radicals to yield peroxides, and then these oxidized lipid species can be detoxified by glutathione and glutathione peroxidase 4 (GPX4) and other components of the cellular antioxidant defense network. Ferroptosis is a form of regulated nonapoptotic cell death involving overwhelming iron-dependent lipid peroxidation. Here, we review the functions and regulation of lipid peroxidation, ferroptosis, and the antioxidant network in diverse species, including humans, other mammals and vertebrates, plants, invertebrates, yeast, bacteria, and archaea. We also discuss the potential evolutionary roles of lipid peroxidation and ferroptosis.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Ros ; Cell Death ; Ferroptosis ; Iron ; Lipid Peroxidation ; Vitamin E
ISSN (print) / ISBN 0890-9369
e-ISSN 1549-5477
Zeitschrift Genes and Development
Quellenangaben Band: 32, Heft: 9-10, Seiten: 602-619 Artikelnummer: , Supplement: ,
Verlag Cold Spring Harbor Laboratory Press
Begutachtungsstatus Peer reviewed