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Cárdenas, A.* ; Villalba, A.* ; de Juan Romero, C.* ; Picó, E.* ; Kyrousi, C.* ; Tzika, A.C.* ; Tessier-Lavigne, M.* ; Ma, L.* ; Drukker, M. ; Cappello, S.* ; Borrell, V.*

Evolution of cortical neurogenesis in amniotes controlled by robo signaling levels.

Cell 174, 590-606.e21 (2018)
Publ. Version/Full Text Research data DOI
Open Access Gold (Paid Option)
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Cerebral cortex size differs dramatically between reptiles, birds, and mammals, owing to developmental differences in neuron production. In mammals, signaling pathways regulating neurogenesis have been identified, but genetic differences behind their evolution across amniotes remain unknown. We show that direct neurogenesis from radial glia cells, with limited neuron production, dominates the avian, reptilian, and mammalian paleocortex, whereas in the evolutionarily recent mammalian neocortex, most neurogenesis is indirect via basal progenitors. Gain- and loss-of-function experiments in mouse, chick, and snake embryos and in human cerebral organoids demonstrate that high Slit/Robo and low Dll1 signaling, via Jag1 and Jag2, are necessary and sufficient to drive direct neurogenesis. Attenuating Robo signaling and enhancing Dll1 in snakes and birds recapitulates the formation of basal progenitors and promotes indirect neurogenesis. Our study identifies modulation in activity levels of conserved signaling pathways as a primary mechanism driving the expansion and increased complexity of the mammalian neocortex during amniote evolution.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Notch ; Pax6 ; Tbr2 ; Electroporation ; Evolution ; Intermediate Progenitor ; Microcephaly ; Radial Glia; Outer Subventricular Zone; Progenitor-cell Division; Radial Glial-cells; Mammalian Telencephalon; Mouse Telencephalon; Basal Progenitors; Olfactory-bulb; Neurons Arise; Axon Guidance; Neural Stem
ISSN (print) / ISBN 0092-8674
e-ISSN 1097-4172
Journal Cell
Quellenangaben Volume: 174, Issue: 3, Pages: 590-606.e21 Article Number: , Supplement: ,
Publisher Cell Press
Publishing Place Cambridge, Mass.
Reviewing status Peer reviewed