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Baghin, V.* ; Lauffer, F.* ; Garzorz-Stark, N.* ; Krause, L. ; Jargosch, M.* ; Eyerich, S. ; Eyerich, K.*

Predictive models for the natural course of atopic dermatitis in childhood based on serum parameters and clinical attributes.

Exp. Dermatol. 27, E17-E17 (2018)
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Flatworms of the species Schmidtea mediterranea are immortal-adult animals contain a large pool of pluripotent stem cells that continuously differentiate into all adult cell types. Therefore, single-cell transcriptome profiling of adult animals should reveal mature and progenitor cells. By combining perturbation experiments, gene expression analysis, a computational method that predicts future cell states from transcriptional changes, and a lineage reconstruction method, we placed all major cell types onto a single lineage tree that connects all cells to a single stem cell compartment. We characterized gene expression changes during differentiation and discovered cell types important for regeneration. Our results demonstrate the importance of single-cell transcriptome analysis for mapping and reconstructing fundamental processes of developmental and regenerative biology at high resolution.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Meeting abstract
Schlagwörter Planarian Schmidtea-mediterranea; Stem-cells; Rna-seq; Gene-expression; Regeneration; Pluripotency; Trajectories; Organism; Tissues; System
ISSN (print) / ISBN 0906-6705
e-ISSN 1600-0625
Quellenangaben Band: 27, Heft: 3, Seiten: E17-E17 Artikelnummer: , Supplement: ,
Verlag Wiley
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Begutachtungsstatus