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Preclinical mouse models for the evaluation of novel techniques in particle therapy.

In: Advances in Radiation Therapy. Basel ; Freiburg: Karger, 2018. 122-129 (Prog. Tumor Res. ; 44)
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Preclinical mouse models that allow the evaluation of novel techniques in radiotherapy using charged particles like protons or heavier ions are discussed here. Focused beams of protons or carbon ions offer distinct physical characteristics that might contribute to an overall improved risk-benefit profile in radiotherapy. In the last decade, novel concepts in radiotherapy aimed to optimize the delivery of high radiation doses to the tumor while sparing the surrounding healthy tissue. 2D in vitro tumor cell cultures provide experimental models to determine the radiosensitivity of isolated cells to different radiation qualities. However, these cell culture models are not capable of mimicking the complexity and heterogeneity of 3-dimensionally growing clinical tumors with their individual tumor microenvironment. Therefore, small animal tumor models are urgently needed to study radiation responses after particle radiotherapy in vivo. Here we describe the recent developments and the accurate testing of novel techniques in particle radiotherapy using up-to-date preclinical animal models.
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Publication type Article: Edited volume or book chapter
Keywords Planarian Schmidtea-mediterranea; Stem-cells; Rna-seq; Gene-expression; Regeneration; Pluripotency; Trajectories; Organism; Tissues; System
ISSN (print) / ISBN 2296-1895
e-ISSN 2296-1887
Book Volume Title Advances in Radiation Therapy
Quellenangaben Volume: 44, Issue: , Pages: 122-129 Article Number: , Supplement: ,
Publisher Karger
Publishing Place Basel ; Freiburg