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Reiss, R.* ; Ehlert, S.* ; Heide, J.* ; Pütz, M.* ; Förster, T.* ; Zimmermann, R.

Ambient pressure laser desorption-chemical ionization mass spectrometry for fast and reliable detection of explosives, drugs, and their precursors.

Appl. Sci. 8:933 (2018)
Verlagsversion Forschungsdaten DOI
Open Access Gold
Creative Commons Lizenzvertrag
Fast and reliable information is crucial for first responders to draw correct conclusions at crime scenes. An ambient pressure laser desorption (APLD) mass spectrometer is introduced for this scenario, which enables detecting substances on surfaces without sample pretreatment. It is especially useful for substances with low vapor pressure and thermolabile ones. The APLD allows for the separation of desorption and ionization into two steps and, therefore, both can be optimized separately. Within this work, an improved version of the developed system is shown that achieves limits of detection (LOD) down to 500 pg while remaining fast and flexible. Furthermore, realistic scenarios are applied to prove the usability of this system in real-world issues. For this purpose, post-blast residues of a bomb from the Second World War were analyzed, and the presence of PETN was proven without sample pretreatment. In addition, the analyzable substance range could be expanded by various drugs and drug precursors. Thus, the presented instrumentation can be utilized for an increased number of forensically important compound classes without changing the setup. Drug precursors revealed a LOD ranging from 6 to 100 ng. Drugs such as cocaine hydrochloride, heroin, (3,4-methylendioxy-methamphetamine) hydrochloride (MDMA) hydrochloride, and others exhibit a LOD between 10 to 200 ng.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Apld ; Drugs ; Explosives ; Post Blast Residue Detection ; Mass Spectrometry ; Chemical Ionization ; On-line Measurement ; Forensic Chemistry ; Mapping; Ion Mobility Spectrometry; Thermal-desorption; Illicit Drugs; Spectroscopy; Desorption/ionization; Samples; Dart; Ms; Identification; Chromatography
ISSN (print) / ISBN 2076-3417
e-ISSN 2076-3417
Zeitschrift Applied Sciences
Quellenangaben Band: 8, Heft: 6, Seiten: , Artikelnummer: 933 Supplement: ,
Verlag MDPI
Verlagsort Basel
Begutachtungsstatus Peer reviewed