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Four-dimensional optoacoustic temperature mapping in laser-induced thermotherapy.

Proc. SPIE 10494:104940D (2018)
Postprint DOI
Open Access Green
Downloading of the abstract is permitted for personal use only. Photoablative laser therapy is in common use for selective destruction of malignant masses, vascular and brain abnormalities. Tissue ablation and coagulation are irreversible processes occurring shortly after crossing a certain thermal exposure threshold. As a result, accurate mapping of the temperature field is essential for optimizing the outcome of these clinical interventions. Here we demonstrate four-dimensional optoacoustic temperature mapping of the entire photoablated region. Accuracy of the method is investigated in tissue-mimicking phantom experiments. Deviations of the volumetric optoacoustic temperature readings provided at 40ms intervals remained below 10% for temperature elevations above 3°C, as validated by simultaneous thermocouple measurements. The excellent spatio-temporal resolution of the new temperature monitoring approach aims at improving safety and efficacy of laser-based photothermal procedures.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Ablation Of Tissue ; Optoacoustic Tomography ; Temperature ; Thermal Treatments
ISSN (print) / ISBN 0277-786X
e-ISSN 1996-756X
Zeitschrift Proceedings of SPIE
Quellenangaben Band: 10494, Heft: , Seiten: , Artikelnummer: 104940D Supplement: ,
Verlag SPIE
Begutachtungsstatus Peer reviewed