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Magnetic molecularly imprinted polymer prepared by microwave heating for confirmatory determination of chloramphenicol in chicken feed using high-performance liquid chromatography-tandem mass spectrometry.
J. Environ. Sci. Health B 53, 738-745 (2018)
DOI Verlagsversion bestellen
A magnetic molecularly imprinted polymer (MMIP) for chloramphenicol was prepared using a surface-imprinted and microwave-heating-induced polymerization method. The surfaces of the magnetic particles were first double-bond functionalized with 3-(trimethoxysilyl)propyl methacrylate (gamma-MPS), followed by the copolymerization of 4-vinyl pyridine (4-VP) and trimethylolpropane trimethacrylate (TRIM) in the presence of chloramphenicol as a template and 1,1-azobis(cyclohexane-carbonitrile) (ABCN) as an initiator in a mixture of dimethyl sulfoxide and water with microwave heating at 80 degrees C. The magnetic polymer possesses supraparamagnetic properties and was used to concentrate and cleanup chicken feed extract, followed by chromatographic separation using a Lichrospher (R) 100 RP C8 column and detection with two multi-reaction monitoring transitions at m/z 321 -> 152 and m/z 321 -> 257. The mean recoveries obtained at two spiking levels were in the range of 94.6-100% The relative intra- and inter-day standard deviations were in the range of 1.4-2.6% and 5.1-5.7%, respectively. The detection limit of the method was 0.12 mu g kg(-1). This confirmatory method was successfully applied to determine chloramphenicol in chicken feed samples.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Chicken Feed ; Chloramphenicol ; Magnetic Molecularly Imprinted Polymers ; Microwave Heating; Solid-phase Extraction; Selective Recognition; Trace Analysis; Animal Feeds; Water; Samples; Antibiotics; Enrichment; Surface; Honey
ISSN (print) / ISBN 0360-1234
Quellenangaben Band: 53, Heft: 11, Seiten: 738-745
Verlagsort 530 Walnut Street, Ste 850, Philadelphia, Pa 19106 Usa
Begutachtungsstatus Peer reviewed
Institut(e) Research Unit Analytical BioGeoChemistry (BGC)