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Li, Z.M. ; Hernandez-Moreno, D. ; Main, K.M.* ; Skakkebæk, N.E.* ; Kiviranta, H.* ; Toppari, J.* ; Feldt-Rasmussen, U.* ; Shen, H.* ; Schramm, K.-W. ; de Angelis, M.

Association of in utero persistent organic pollutant exposure with placental thyroid hormones.

Endocrinology 159, 3473-3481 (2018)
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In utero exposure to persistent organic pollutants (POPs) can result in thyroid function disorder, leading to concerns about their impact on fetal and neonatal development. The associations between placental levels of various POPs and thyroid hormones (THs) were investigated. In a prospective Danish study initially established for assessing congenital cryptorchidism, 58 placenta samples were collected from mothers of boys born with (n =28) and without (n =30) cryptorchidism. The concentrations of polybrominated diphenyl ethers (PBDEs), polychlorinated biphenyls (PCBs), polychlorinated dibenzo-p-dioxins/furans (PCDD/Fs), organotin chemicals (OTCs), organochlorine pesticides (OCPs), T 4, T 3, and rT 3 were measured. The associations between placental THs and various POPs were analyzed using multiple linear regression. Five PBDEs, 35 PCBs, 14 PCDD/Fs, 3 OTCs, 25 OCPs, T 4, T 3, and rT 3 were measured. No correlation between THs and the odds of cryptorchidism was found. Several POPs were significantly associated with THs: (1) T 4 was inversely associated with BDEs 99, 100, Σ PBDE, and 2378-TeCDD, and positively associated with 1234678-HpCDF; (2) T 3 was positively associated with 2378-TeCDF and 12378-PeCDF; and (3) rT 3 was positively associated with PCB 81, 12378-PeCDF, and 234678-HxCDF, and inversely associated with tributyltin, Σ OTC, and methoxychlor. These results revealed that POP exposures were associated with TH levels in placenta, which may be a possible mechanism for the impacts of POP exposures on children's growth and development. This study provides new insight into the complexity of thyroid-disrupting properties of POPs. More research is needed to elucidate the biological consequences of POP exposures.
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Publication type Article: Journal article
Document type Scientific Article
ISSN (print) / ISBN 0013-7227
e-ISSN 1945-7170
Journal Endocrinology
Quellenangaben Volume: 159, Issue: 10, Pages: 3473-3481 Article Number: , Supplement: ,
Publisher Endocrine Society
Publishing Place Chevy Chase, Md.
Reviewing status Peer reviewed