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Kopf, S.* ; Groener, J.B.* ; Kender, Z.* ; Fleming, T.* ; Brune, M.* ; Riedinger, C.* ; Volk, N.* ; Herpel, E.* ; Pesta, D.* ; Szendroedi, J.* ; Wielpuetz, M.O.* ; Kauczor, H.U.* ; Katus, H.A.* ; Kreuter, M.* ; Nawroth, P.P.

Breathlessness and restrictive lung disease: AniImportant diabetes-related feature in patients with type 2 diabetes.

Respiration 96, 29-40 (2018)
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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Background: Diabetes mellitus is a significant comorbidity of interstitial lung disease (ILD). Objectives: The aim of this study was to investigate the incidence of restrictive lung disease (RLD) and ILD in patients with prediabetes and type 2 diabetes (T2D). Methods: Forty-eight nondiabetics, 68 patients with prediabetes, 29 newly diagnosed T2D, and 110 patients with long-term T2D were examined for metabolic control, diabetes-related complications, breathlessness, and lung function. Five participants with T2D, breathlessness, and RLD underwent multidetector computed tomography (MDCT) and a Six-Minute Walk Test (6MWT). Lung tissue from 4 patients without diabetes and from 3 patients with T2D was histologically examined for presence of pulmonary fibrosis. Results: Breathlessness in combination with RLD was significantly increased in patients with prediabetes and T2D (p < 0.01). RLD was found in 9% of patients with prediabetes, in 20% of patients with newly diagnosed T2D, and in 27% of patients with long-term T2D. Thus, patients with long-term T2D had an increased risk of RLD (OR 5.82 [95% CI 1.71-20.5], p < 0.01). RLD was significantly associated with glucose metabolism and albuminuria (p < 0.01); furthermore, presence of nephropathy increased the risk of RLD (OR 8.57 [95% CI 3.4-21.9], p < 0.01) compared to nondiabetics. MDCT revealed ILD in 4 patients, the 6MWT correlated with the extent of ILD, and histological analysis showed fibrosing ILD in patients with T2D. Conclusions: This study demonstrates increased breathlessness and a high prevalence of RLD in patients with T2D, indicating an association between diabetes and fibrosing ILD.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Fibrosing Interstitial Lung Disease ; Type 2 Diabetes ; Albuminuria ; Diabetes-related Complications; Idiopathic Pulmonary-fibrosis; Mellitus; Dyspnea; Statement; Diagnosis; Neuropathy; Equations; Indicator; Multiple; Tests
ISSN (print) / ISBN 0025-7931
e-ISSN 1423-0356
Zeitschrift Respiration
Quellenangaben Band: 96, Heft: 1, Seiten: 29-40 Artikelnummer: , Supplement: ,
Verlag Karger
Verlagsort Allschwilerstrasse 10, Ch-4009 Basel, Switzerland
Begutachtungsstatus Peer reviewed