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Rospleszcz, S. ; Schafnitzel, A.* ; Koenig, W.* ; Lorbeer, R.* ; Auweter, S.* ; Huth, C. ; Rathmann, W.* ; Heier, M. ; Linkohr, B. ; Meisinger, C. ; Hetterich, H.* ; Bamberg, F.* ; Peters, A.

Association of glycemic status and segmental left ventricular wall thickness in subjects without prior cardiovascular disease: A cross-sectional study.

BMC Cardiovasc. Disord. 18:162 (2018)
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Background: Left ventricular (LV) hypertrophy and changes in LV geometry are associated with increased cardiovascular mortality. Subjects with type 2 diabetes have an increased risk of such alterations in cardiac morphology. We sought to assess the association of glycemic status and LV wall thickness measured by cardiac magnetic resonance (CMR), and potential interactions of hypertension and diabetes. Methods: CMR was performed on 359 participants from a cross-sectional study nested in a population-based cohort (KORA FF4) free of overt cardiovascular disease. Participants were classified according to their glycemic status as either control (normal glucose metabolism), prediabetes or type 2 diabetes. Segmentation of the left ventricle was defined according to the American Heart Association (AHA) 16-segment model. Measurements of wall thickness were obtained at end-diastole and analyzed by linear regression models adjusted for traditional cardiovascular risk factors. Results: LV wall thickness gradually increased from normoglycemic controls to subjects with prediabetes and subjects with diabetes (8.8 ± 1.4 vs 9.9 ± 1.4 vs 10.5 ± 1.6 mm, respectively). The association was independent of hypertension and traditional cardiovascular risk factors (β-coefficient: 0.44 mm for prediabetes and 0.70 mm for diabetes, p-values compared to controls: p = 0.007 and p = 0.004, respectively). Whereas the association of glycemic status was strongest for the mid-cavity segments, the association of hypertension was strongest for the basal segments. Conclusion: Abnormal glucose metabolism, including pre-diabetes, is associated with increased LV wall thickness independent of hypertension.
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Publication type Article: Journal article
Document type Scientific Article
Keywords 16-segment Model ; Cardiac Magnetic Resonance Imaging ; Diabetes ; Left Ventricular Wall Thickness ; Prediabetes; Cardiac Magnetic-resonance; Metabolic Risk-factors; Insulin-resistance; Diabetes-mellitus; Atherosclerosis Mesa; Systolic Function; Lv Mass; Hypertrophy; Heart; Hypertension
e-ISSN 1471-2261
Quellenangaben Volume: 18, Issue: 1, Pages: , Article Number: 162 Supplement: ,
Publisher BioMed Central
Publishing Place London
Reviewing status Peer reviewed