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Tackling standardization in fluorescence molecular imaging.

Nat. Photonics 12, 505-515 (2018)
Open Access Green as soon as Postprint is submitted to ZB.
The emerging clinical use of targeted fluorescent agents heralds a shift in intraoperative imaging practices that overcome the limitations of human vision. However, in contrast to established radiological methods, no appropriate performance specifications and standards have been established in fluorescence molecular imaging. Moreover, the dependence of fluorescence signals on many experimental parameters and the use of wavelengths ranging from the visible to short-wave infrared (400–1,700 nm) complicate quality control in fluorescence molecular imaging. Here, we discuss the experimental parameters that critically affect fluorescence molecular imaging accuracy, and introduce the concept of high-fidelity fluorescence imaging as a means for ensuring reliable reproduction of fluorescence biodistribution in tissue.
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Publication type Article: Journal article
Document type Review
Keywords In-vivo; Quantum Dots; Optical-properties; Modulated Iccd; Real-time; Cancer; Performance; Disease; Tumors; Brain
ISSN (print) / ISBN 1749-4885
e-ISSN 1749-4893
Quellenangaben Volume: 12, Issue: 9, Pages: 505-515 Article Number: , Supplement: ,
Publisher Nature Publishing Group
Publishing Place Macmillan Building, 4 Crinan St, London N1 9xw, England
Reviewing status Peer reviewed