Verlagsversion online verfügbar vsl. 09/2019 Verlagsversion online verfügbar vsl. 09/2019
Atlas of circadian metabolism reveals system-wide coordination and communication between clocks.
Cell 174, 1571-1585.e11 (2018)
Metabolic diseases are often characterized by circadian misalignment in different tissues, yet how altered coordination and communication among tissue clocks relate to specific pathogenic mechanisms remains largely unknown. Applying an integrated systems biology approach, we performed 24-hr metabolomics profiling of eight mouse tissues simultaneously. We present a temporal and spatial atlas of circadian metabolism in the context of systemic energy balance and under chronic nutrient stress (high-fat diet [HFD]). Comparative analysis reveals how the repertoires of tissue metabolism are linked and gated to specific temporal windows and how this highly specialized communication and coherence among tissue clocks is rewired by nutrient challenge. Overall, we illustrate how dynamic metabolic relationships can be reconstructed across time and space and how integration of circadian metabolomics data from multiple tissues can improve our understanding of health and disease.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Circadian Rhythms ; Circadiomics ; Clock ; High-fat Diet ; Metabolism ; Metabolomics; Brown Adipose-tissue; Amino-acid-metabolism; Insulin-resistance; Nutritional Challenge; Mitochondrial Proton; Cellular-metabolism; Purine Nucleotides; Signaling Pathways; Skeletal-muscle; Glucose-uptake
ISSN (print) / ISBN 0092-8674
Quellenangaben Band: 174, Heft: 6, Seiten: 1571-1585.e11
Verlag Cell Press
Verlagsort Cambridge, Mass.