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Glucose tolerance and insulin sensitivity define adipocyte transcriptional programs in human obesity.
Mol. Metab.:doi:10.1016/j.molmet.2018.09.004 (2018)
OBJECTIVE: Although debated, metabolic health characterizes 10-25% of obese individuals and reduces risk of developing life-threatening co-morbidities. Adipose tissue is a recognized endocrine organ important for the maintenance of whole-body metabolic health. Adipocyte transcriptional signatures of healthy and unhealthy obesity are largely unknown. METHODS: Here, we used a small cohort of highly characterized obese individuals discordant for metabolic health, characterized their adipocytes transcriptional signatures, and cross-referenced them to mouse phenotypic and human GWAs databases. RESULTS AND CONCLUSIONS: Our study showed that glucose intolerance and insulin resistance co-operate to remodel adipocyte transcriptome. We also identified the Nuclear Export Mediator Factor (NEMF) and the Ectoderm-Neural Cortex 1 (ENC1) as novel potential targets in the management of metabolic health in human obesity.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Glucose Tolerance ; Insulin Sensitivity ; Mouse Genetics ; Obesity ; Systemic Phenotyping ; Transcriptomics
e-ISSN 2212-8778
Zeitschrift Molecular Metabolism
Quellenangaben Band: , Heft: , Seiten: , Artikelnummer: doi:10.1016/j.molmet.2018.09.004 Supplement: ,
Verlag Elsevier Science BV
Verlagsort Amsterdam
Begutachtungsstatus peer-reviewed