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Brankatschk, M.* ; Gutmann, T. ; Knittelfelder, O.* ; Palladini, A. ; Prince, E.* ; Grzybek, M. ; Brankatschk, B. ; Shevchenko, A.* ; Coskun, Ü. ; Eaton, S.*

A temperature-dependent switch in feeding preference improves Drosophila development and survival in the cold.

Dev. Cell 46, 781-793.e4 (2018)
Verlagsversion DOI
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How cold-blooded animals acclimate to temperature and what determines the limits of their viable temperature range are not understood. Here, we show that Drosophila alter their dietary preference from yeast to plants when temperatures drop below 15 degrees C and that the different lipids present in plants improve survival at low temperatures. We show that Drosophila require dietary unsaturated fatty acids present in plants to adjust membrane fluidity and maintain motor coordination. Feeding on plants extends lifespan and survival for many months at temperatures consistent with overwintering in temperate climates. Thus, physiological alterations caused by a temperature-dependent dietary shift could help Drosophila survive seasonal temperature changes.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Drosophila Melanogaster ; Foraging Behavior ; Homeoviscous Adaption ; Insulin Signaling ; Lifespan ; Lipidomics ; Membrane Fluidity ; Overwintering ; Temperature Acclimation; Fatty-acid-composition; Seasonal-changes; Membrane-lipids; Saccharomyces-cerevisiae; Overwintering Larvae; Thermal Adaptation; Shotgun Lipidomics; Cell-membranes; Na+/k+-atpase; Chill-coma
ISSN (print) / ISBN 1534-5807
e-ISSN 1878-1551
Zeitschrift Developmental Cell
Quellenangaben Band: 46, Heft: 6, Seiten: 781-793.e4 Artikelnummer: , Supplement: ,
Verlag Elsevier
Verlagsort 50 Hampshire St, Floor 5, Cambridge, Ma 02139 Usa
Begutachtungsstatus Peer reviewed
Institut(e) Institute for Pancreatic Beta Cell Research (IPI)