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Ntziachristos, V. ; Pleitez, M.A. ; Aime, S.* ; Brindle, K.M.*

Emerging technologies to image tissue metabolism.

Cell Metab. 29, 518-538 (2019)
Publ. Version/Full Text Postprint DOI
Open Access Green
Due to the implication of altered metabolism in a large spectrum of tissue function and disease, assessment of metabolic processes becomes essential in managing health. In this regard, imaging can play a critical role in allowing observation of biochemical and physiological processes. Nuclear imaging methods, in particular positron emission tomography, have been widely employed for imaging metabolism but are mainly limited by the use of ionizing radiation and the sensing of only one parameter at each scanning session. Observations in healthy individuals or longitudinal studies of disease could markedly benefit from non-ionizing, multi-parameter imaging methods. We therefore focus this review on progress with the non-ionizing radiation methods of MRI, hyperpolarized magnetic resonance and magnetic resonance spectroscopy, chemical exchange saturation transfer, and emerging optoacoustic (photoacoustic) imaging. We also briefly discuss the role of nuclear and optical imaging methods for research and clinical protocols.
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Publication type Article: Journal article
Document type Review
Keywords Cest ; Mri ; Pet ; Blood Oxygenation ; Brown Adipose Tissue ; Diabetes ; Lipid ; Optoacoustic ; Photoacoustic ; Ultrasound; Mri Contrast Agent; Multispectral Optoacoustic Tomography; Hyperpolarized Magnetic-resonance; Parahydrogen Induced Polarization; Dynamic Nuclear-polarization; In-vivo; Glucose-uptake; Treatment Response; Tumor Response; Live Cells
ISSN (print) / ISBN 1550-4131
e-ISSN 1932-7420
Journal Cell Metabolism
Quellenangaben Volume: 29, Issue: 3, Pages: 518-538 Article Number: , Supplement: ,
Publisher Elsevier
Publishing Place 50 Hampshire St, Floor 5, Cambridge, Ma 02139 Usa
Reviewing status Peer reviewed