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Blume, J.* ; Ziętara, N.* ; Witzlau, K.* ; Liu, Y.* ; Ortiz, O. ; Puchałka, J.* ; Winter, S.J.* ; Kunze-Schumacher, H.* ; Saran, N.* ; Düber, S.* ; Roy, B.* ; Weiss, S.* ; Klein, C.* ; Wurst, W. ; Łyszkiewicz, M.* ; Krueger, A.*

miR-191 modulates B-cell development and targets transcription factors E2A, Foxp1, and Egr1.

Eur. J. Immunol. 49, 121-132 (2019)
Verlagsversion Postprint Forschungsdaten DOI
Open Access Green
The interdependence of posttranscriptional gene regulation via miRNA and transcriptional regulatory networks in lymphocyte development is poorly understood. Here, we identified miR-191 as direct upstream modulator of a transcriptional module comprising the transcription factors Foxp1, E2A, and Egr1. Deletion as well as ectopic expression of miR-191 resulted in developmental arrest in B lineage cells, indicating that fine tuning of the combined expression levels of Foxp1, E2A, and Egr1, which in turn control somatic recombination and cytokine-driven expansion, constitutes a prerequisite for efficient B-cell development. In conclusion, we propose that miR-191 acts as a rheostat in B-cell development by fine tuning a key transcriptional program.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter B Cells ; Lymphocyte Development ; Mirna ; Mir-191 ; Transcriptional Factors; Gene-expression; Differentiation; Recombination; Proteins; Proliferation; Binding; Family; Growth; E47; Rna
ISSN (print) / ISBN 0014-2980
e-ISSN 1521-4141
Quellenangaben Band: 49, Heft: 1, Seiten: 121-132 Artikelnummer: , Supplement: ,
Verlag Wiley
Verlagsort Hoboken
Begutachtungsstatus Peer reviewed