Postprint online available 10/2019 Open Access Green as soon as is submitted to ZB.
miR-191 modulates B-cell development and targets transcription factors E2A, Foxp1, and Egr1.
Eur. J. Immunol. 49, 121-132 (2019)
The interdependence of posttranscriptional gene regulation via miRNA and transcriptional regulatory networks in lymphocyte development is poorly understood. Here, we identified miR-191 as direct upstream modulator of a transcriptional module comprising the transcription factors Foxp1, E2A, and Egr1. Deletion as well as ectopic expression of miR-191 resulted in developmental arrest in B lineage cells, indicating that fine tuning of the combined expression levels of Foxp1, E2A, and Egr1, which in turn control somatic recombination and cytokine-driven expansion, constitutes a prerequisite for efficient B-cell development. In conclusion, we propose that miR-191 acts as a rheostat in B-cell development by fine tuning a key transcriptional program.
Edit extra informations Login
Publication type Article: Journal article
Document type Scientific Article
Keywords B Cells ; Lymphocyte Development ; Mirna ; Mir-191 ; Transcriptional Factors; Gene-expression; Differentiation; Recombination; Proteins; Proliferation; Binding; Family; Growth; E47; Rna
Institute(s) Institute of Developmental Genetics (IDG)