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MicroRNAs coordinately regulate protein complexes.
BMC Syst. Biol. 5:136 (2011)
BACKGROUND: In animals, microRNAs (miRNAs) regulate the protein synthesis of their target messenger RNAs (mRNAs) by either translational repression or deadenylation. miRNAs are frequently found to be co-expressed in different tissues and cell types, while some form polycistronic clusters on genomes. Interactions between targets of co-expressed miRNAs (including miRNA clusters) have not yet been systematically investigated.RESULTS: Here we integrated information from predicted and experimentally verified miRNA targets to characterize protein complex networks regulated by human miRNAs. We found striking evidence that individual miRNAs or co-expressed miRNAs frequently target several components of protein complexes. We experimentally verified that the miR-141-200c cluster targets different components of the CtBP/ZEB complex, suggesting a potential orchestrated regulation in epithelial to mesenchymal transition. CONCLUSIONS: Our findings indicate a coordinate posttranscriptional regulation of protein complexes by miRNAs. These provide a sound basis for designing experiments to study miRNA function at a systems level.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter mir-200 family; interaction network; mesenchymal transition; repressors zeb1; cancer-cells; drosophila; expression; evolution; cluster; genes
e-ISSN 1752-0509
Zeitschrift BMC Systems Biology
Quellenangaben Band: 5, Heft: , Seiten: , Artikelnummer: 136 Supplement: ,
Verlag BioMed Central
Begutachtungsstatus peer-reviewed