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Mesothelial to mesenchyme transition as a major developmental and pathological player in trunk organs and their cavities.

Comm. Biol. 1:170 (2018)
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Open Access Gold
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The internal organs embedded in the cavities are lined by an epithelial monolayer termed the mesothelium. The mesothelium is increasingly implicated in driving various internal organ pathologies, as many of the normal embryonic developmental pathways acting in mesothelial cells, such as those regulating epithelial-to-mesenchymal transition, also drive disease progression in adult life. Here, we summarize observations from different animal models and organ systems that collectively point toward a central role of epithelial-to-mesenchymal transition in driving tissue fibrosis, acute scarring, and cancer metastasis. Thus, drugs targeting pathways of mesothelium's transition may have broad therapeutic benefits in patients suffering from these diseases.
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Publication type Article: Journal article
Document type Review
ISSN (print) / ISBN 2399-3642
e-ISSN 2399-3642
Quellenangaben Volume: 1, Issue: , Pages: , Article Number: 170 Supplement: ,
Publisher Springer
Publishing Place London
Reviewing status Peer reviewed