PuSH - Publikationsserver des Helmholtz Zentrums München

Ultrashort broadband cooperative pulses for multidimensional bio-molecular NMR experiments.
Angew. Chem.-Int. Edit. 57, 14498-14502 (2018)
online verfügbar vsl. 11/2019 
NMR spectroscopy at ultra-high magnetic fields requires improved radiofrequency (rf) pulses to cover the increased spectral bandwidth. Optimized 90 degrees pulse pairs were introduced as Ramsey-type cooperative (Ram-COOP) pulses for biomolecular NMR applications. The Ram-COOP element provides broadband excitation with enhanced sensitivity and reduced artifacts even at magnetic fields >1.0GHz H-1 Larmor frequency (23T). A pair of 30s Ram-COOP pulses achieves an excitation bandwidth of 100kHz with a maximum rf field of 20kHz, more than three-fold improved compared to excitation by rectangular pulses. Ram-COOP pulses exhibit little offset-dependent phase errors and are robust to rf inhomogeneity. The performance of the Ram-COOP element is experimentally confirmed with heteronuclear multidimensional NMR experiments, applied to proteins and nucleic acids. Ram-COOP provides broadband excitation at low rf field strength suitable for application at current magnetic fields and beyond 23T.
Weitere Metriken?
Zusatzinfos bearbeiten [➜Einloggen]
Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Hmqc ; Cooperative Broadband Excitation Pulses ; High-field Nmr Spectroscopy ; Noesy ; Optimal Control Theory; Adiabatic Pulses; Spectroscopy; Inversion; Limits
ISSN (print) / ISBN 1433-7851
e-ISSN 1521-3773
Zeitschrift Angewandte Chemie - Internationale Edition
Quellenangaben Band: 57, Heft: 44, Seiten: 14498-14502 Artikelnummer: , Supplement: ,
Verlag Wiley-VCH
Verlagsort Weinheim
Begutachtungsstatus peer-reviewed