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Cohort-wide deep whole genome sequencing and the allelic architecture of complex traits.

Nat. Commun. 9:4674 (2018)
Publishers Version Research data DOI PMC
Open Access Gold
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as soon as is submitted to ZB.
The role of rare variants in complex traits remains uncharted. Here, we conduct deep whole genome sequencing of 1457 individuals from an isolated population, and test for rare variant burdens across six cardiometabolic traits. We identify a role for rare regulatory variation, which has hitherto been missed. We find evidence of rare variant burdens that are independent of established common variant signals (ADIPOQ and adiponectin, P = 4.2 x 10(-8); APOC3 and triglyceride levels, P = 1.5 x 10(-26)), and identify replicating evidence for a burden associated with triglyceride levels in FAM189B (P = 2.2 x 10(-8)), indicating a role for this gene in lipid metabolism.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Recent Positive Selection; Human-populations; Genetic-variation; Association; Variants; Sample; Apoc3; Expression; Framework; Inference
Reviewing status
Institute(s) Institute of Translational Genomics (ITG)