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Recent advances in capillary electrophoresis-mass spectrometry: Instrumentation, methodology and applications.
Electrophoresis 40, 79-112 (2019)
Capillary electrophoresis (CE) offers fast and high-resolution separation of charged analytes from small injection volumes. Coupled to mass spectrometry (MS), it represents a powerful analytical technique providing (exact) mass information and enables molecular characterization based on fragmentation. Although hyphenation of CE and MS is not straightforward, much emphasis has been placed on enabling efficient ionization and user-friendly coupling. Though several interfaces are now commercially available, research on more efficient and robust interfacing with nano-electrospray ionization (ESI), matrix-assisted laser desorption/ionization (MALDI) and inductively coupled plasma mass spectrometry (ICP) continues with considerable results. At the same time, CE-MS has been used in many fields, predominantly for the analysis of proteins, peptides and metabolites. This review belongs to a series of regularly published articles, summarizing 248 articles covering the time between June 2016 and May 2018. Latest developments on hyphenation of CE with MS as well as instrumental developments such as two-dimensional separation systems with MS detection are mentioned. Furthermore, applications of various CE-modes including capillary zone electrophoresis (CZE), nonaqueous capillary electrophoresis (NACE), capillary gel electrophoresis (CGE) and capillary isoelectric focusing (CIEF) coupled to MS in biological, pharmaceutical and environmental research are summarized.
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Publikationstyp Artikel: Journalartikel
Schlagwörter Capillary Electrophoresis ; Ce-ms ; Mass Spectrometry; Solid-phase Extraction; Sheath-flow Interface; Ce-icp-ms; Contactless Conductivity Detection; Organic-matter Nom; High Peak-capacity; Zone-electrophoresis; Monoclonal-antibody; Gold Nanoparticles; Single-cell
ISSN (print) / ISBN 0173-0835
Quellenangaben Band: 40, Heft: 1, Seiten: 79-112
Verlagsort 111 River St, Hoboken 07030-5774, Nj Usa
Begutachtungsstatus Peer reviewed
Institut(e) Research Unit Analytical BioGeoChemistry (BGC)