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Kalel, V.C.* ; Mäser, P.* ; Sattler, M. ; Erdmann, R.* ; Popowicz, G.M.

Come, sweet death: Targeting glycosomal protein import for antitrypanosomal drug development.

Curr. Opin. Microbiol. 46, 116-122 (2018)
DOI Verlagsversion bestellen
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Glycosomes evolved as specialized system for glycolysis in trypanosomatids. These organelle rely on protein import to maintain function. A machinery of peroxin (PEX) proteins is responsible for recognition and transport of glycosomal proteins to the organelle. Disruption of PEX-based import system was expected to be a strategy against trypanosomatids. Recently, a proof of this hypothesis has been presented. Here, we review current information about trypanosomatids' glycosomal transport components as targets for new trypanocidal therapies.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Trypanosoma-brucei; Functional-characterization; Receptors Pex5; Compartmentation; Identification; Recognition; Glycolysis; Phosphofructokinase; Hexokinase; Inhibitors
ISSN (print) / ISBN 1369-5274
e-ISSN 1879-0364
Quellenangaben Band: 46, Heft: , Seiten: 116-122 Artikelnummer: , Supplement: ,
Verlag Current Biology Ltd.
Verlagsort London
Begutachtungsstatus Peer reviewed