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Penkov, S. ; Mitroulis, I.* ; Hajishengallis, G.* ; Chavakis, T.

Immunometabolic crosstalk: An ancestral principle of trained immunity?

Trends Immunol. 40, 1-11 (2019)
Publ. Version/Full Text DOI
Open Access Green as soon as Postprint is submitted to ZB.
Memory was traditionally considered an exclusive hallmark of adaptive immunity. This dogma was challenged by recent reports that myeloid cells can retain 'memory' of earlier challenges, enabling them to respond strongly to a secondary stimulus. This process, designated 'trained immunity', is initiated by modulation of precursors of myeloid cells in the bone marrow. The ancestral innate immune system of lower organisms (e.g., Caenorhabditis elegans) can build long-lasting memory that modifies responses to secondary pathogen encounters. We posit that changes in cellular metabolism may be a common denominator of innate immune memory from lower animals to mammals. We discuss evidence from C. elegans and murine/human systems supporting the concept of an ancestral principle regulating innate immune memory by controlling cellular metabolism.
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Publication type Article: Journal article
Document type Review
Keywords Hematopoietic Stem-cells; Elegans Life-span; Innate Immunity; Caenorhabditis-elegans; Clonal Hematopoiesis; C. Elegans; Tissue Macrophages; Energy-metabolism; Molecular-basis; Infection
ISSN (print) / ISBN 1471-4906
e-ISSN 1471-4981
Quellenangaben Volume: 40, Issue: 1, Pages: 1-11 Article Number: , Supplement: ,
Publisher Elsevier
Publishing Place The Boulevard, Langford Lane, Kidlington, Oxford Ox5 1gb, Oxon, England
Reviewing status Peer reviewed
Institute(s) Institute for Pancreatic Beta Cell Research (IPI)