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Oyaga Landa, F.J. ; Ronda Penacoba, S.* ; de Espinosa, F.M.* ; Razansky, D. ; Dean-Ben, X.L.

Four-dimensional optoacoustic monitoring of tissue heating with medium intensity focused ultrasound.

Ultrasonics 94, 117-123 (2018)
Postprint DOI
Open Access Green
Medium-intensity focused ultrasound (MIFU) concerns therapeutic ultrasound interventions aimed at stimulating physiological mechanisms to reinforce healing responses without reaching temperatures that can cause permanent tissue damage. The therapeutic outcome is strongly affected by the temperature distribution in the treated region and its accurate monitoring represents an unmet clinical need. In this work, we investigate on the capacities of four-dimensional optoacoustic tomography to monitor tissue heating with MIFU. Calibration experiments in a tissue-mimicking phantom have confirmed that the optoacoustically-estimated temperature variations accurately match the simultaneously acquired thermocouple readings. The performance of the suggested approach in real tissues was further shown with bovine muscle samples. Volumetric temperature maps were rendered in real time, allowing for dynamic monitoring of the ultrasound focal region, estimation of the peak temperature and the size of the heat-affected volume.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Thermal Treatment Monitoring ; Optoacoustic Tomography ; Photoacoustic Imaging ; Temperature Monitoring ; Therapeutic Ultrasound; Real-time; Therapeutic Ultrasound; Soft-tissue; Thermometry; Ablation
ISSN (print) / ISBN 0041-624x
e-ISSN 1874-9968
Zeitschrift Ultrasonics
Quellenangaben Band: 94, Heft: , Seiten: 117-123 Artikelnummer: , Supplement: ,
Verlag Elsevier
Verlagsort Amsterdam [u.a.]
Begutachtungsstatus Peer reviewed