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Meyer, J.* ; Eley, J.* ; Schmid, T.E. ; Combs, S.E. ; Dendale, R.* ; Prezado, Y.*

Spatially fractionated proton minibeams.

Br. J. Radiol. 91:20180466 (2019)
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Extraordinary normal tissue response to highly spatially fractionated X-ray beams has been explored for over 25 years. More recently, alternative radiation sources have been developed and utilized with the aim to evoke comparable effects. These include protons, which lend themselves well for this endeavour due to their physical depth dose characteristics as well as corresponding variable biological effectiveness. This paper addresses the motivation for using protons to generate spatially fractionated beams and reviews the technological implementations and experimental results to date. This includes simulation and feasibility studies, collimation and beam characteristics, dosimetry and biological considerations as well as the results of in vivo and in vitro studies. Experimental results are emerging indicating an extraordinary normal tissue sparing effect analogous to what has been observed for synchrotron generated X-ray microbeams. The potential for translational research and feasibility of spatially modulated proton beams in clinical settings is discussed.
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Publication type Article: Journal article
Document type Review
Keywords Equivalent Uniform Dose ; Microbeam Radiotherapy ; Normal Tissue Sparing ; Relative Biological Effectiveness ; Spatially Fractionated Radiation Therapy; Microbeam Radiation-therapy; Glioma-bearing Rats; Microplanar Beams; 9l Gliosarcoma; Spinal-cord; Synchrotron; Brain; Radiotherapy; Irradiation; Skin
ISSN (print) / ISBN 0007-1285
e-ISSN 1748-880X
Quellenangaben Volume: 91, Issue: 1095, Pages: , Article Number: 20180466 Supplement: ,
Publisher British Institute of Radiology N.S
Publishing Place 36 Portland Place, London W1n 4at, England
Reviewing status Peer reviewed