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Singh, S.P.* ; Ninov, N.

The triumvirate of beta-cell regeneration: Solutions and bottlenecks to curing diabetes.

Int. J. Dev. Biol. 62, 453-464 (2018)
DOI Verlagsversion bestellen
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
On 11 January 1922 insulin injection was used for the first time in the treatment of diabetes. Even today, daily insulin injections are the life-saving treatment for patients with Type 1 diabetes and advanced Type 2 diabetes. However, insulin injections often fail to achieve full glucose control, which in the long-term leads to multiple complications and mortality. Beta-cells, the natural producers and secretors of insulin, remain the gold-standard in regulating blood glucose levels. In this review, we focus on three strategies aiming at counteracting beta-cell loss in order to gain insulin independence: replacement, replication and protection. The three approaches, together termed as the triumvirate of beta-cell regeneration, may constitute the basis for a future cure for diabetes.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Reprogramming ; Regeneration ; Protection ; Diabetes; Insulin-producing Cells; In-vivo; Centroacinar Cells; Secreting Cells; Stem-cells; Mass; Endocrine; Islets; Liver; Differentiation
ISSN (print) / ISBN 0214-6282
e-ISSN 1696-3547
Quellenangaben Band: 62, Heft: 6-8, Seiten: 453-464 Artikelnummer: , Supplement: ,
Verlag University of the Basque Country Press (UBC Press)
Verlagsort Po Box 1397, Bilbao, Bizkaia E-48080, Spain
Begutachtungsstatus Peer reviewed
Institut(e) Institute for Pancreatic Beta Cell Research (IPI)