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Singh, S.P.* ; Ninov, N.

The triumvirate of beta-cell regeneration: Solutions and bottlenecks to curing diabetes.

Int. J. Dev. Biol. 62, 453-464 (2018)
DOI Order publishers version
Open Access Green as soon as Postprint is submitted to ZB.
On 11 January 1922 insulin injection was used for the first time in the treatment of diabetes. Even today, daily insulin injections are the life-saving treatment for patients with Type 1 diabetes and advanced Type 2 diabetes. However, insulin injections often fail to achieve full glucose control, which in the long-term leads to multiple complications and mortality. Beta-cells, the natural producers and secretors of insulin, remain the gold-standard in regulating blood glucose levels. In this review, we focus on three strategies aiming at counteracting beta-cell loss in order to gain insulin independence: replacement, replication and protection. The three approaches, together termed as the triumvirate of beta-cell regeneration, may constitute the basis for a future cure for diabetes.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Reprogramming ; Regeneration ; Protection ; Diabetes; Insulin-producing Cells; In-vivo; Centroacinar Cells; Secreting Cells; Stem-cells; Mass; Endocrine; Islets; Liver; Differentiation
ISSN (print) / ISBN 0214-6282
e-ISSN 1696-3547
Quellenangaben Volume: 62, Issue: 6-8, Pages: 453-464 Article Number: , Supplement: ,
Publisher University of the Basque Country Press (UBC Press)
Publishing Place Po Box 1397, Bilbao, Bizkaia E-48080, Spain
Reviewing status Peer reviewed
Institute(s) Institute for Pancreatic Beta Cell Research (IPI)