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The triumvirate of beta-cell regeneration: Solutions and bottlenecks to curing diabetes.
Int. J. Dev. Biol. 62, 453-464 (2018)
On 11 January 1922 insulin injection was used for the first time in the treatment of diabetes. Even today, daily insulin injections are the life-saving treatment for patients with Type 1 diabetes and advanced Type 2 diabetes. However, insulin injections often fail to achieve full glucose control, which in the long-term leads to multiple complications and mortality. Beta-cells, the natural producers and secretors of insulin, remain the gold-standard in regulating blood glucose levels. In this review, we focus on three strategies aiming at counteracting beta-cell loss in order to gain insulin independence: replacement, replication and protection. The three approaches, together termed as the triumvirate of beta-cell regeneration, may constitute the basis for a future cure for diabetes.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Reprogramming ; Regeneration ; Protection ; Diabetes; Insulin-producing Cells; In-vivo; Centroacinar Cells; Secreting Cells; Stem-cells; Mass; Endocrine; Islets; Liver; Differentiation
ISSN (print) / ISBN 0214-6282
Quellenangaben Volume: 62, Issue: 6-8, Pages: 453-464
Publisher University of the Basque Country Press (UBC Press)
Publishing Place Po Box 1397, Bilbao, Bizkaia E-48080, Spain
Reviewing status Peer reviewed
Institute(s) Institute for Pancreatic Beta Cell Research (IPI)