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Chung, K.-J. ; Nati, M.* ; Chavakis, T. ; Chatzigeorgiou, A.*

Innate immune cells in the adipose tissue.

Rev. Endocr. Metab. Disord. 19, 283-292 (2018)
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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Immune cells are present in the adipose tissue (AT) and regulate its function. Under lean conditions, immune cells predominantly of type 2 immunity, including eosinophils, M2-like anti-inflammatory macrophages and innate lymphoid cells 2, contribute to the maintenance of metabolic homeostasis within the AT. In the course of obesity, pro-inflammatory immune cells, such as M1-like macrophages, prevail in the AT. Inflammation in the obese AT is associated with the development of metabolic complications such as insulin resistance, type 2 diabetes and cardiovascular disease. Thus, the immune cell-adipocyte crosstalk in the AT is an important regulator of AT function and systemic metabolism. We discuss herein this crosstalk with a special focus on the role of innate immune cells in AT inflammation and metabolic homeostasis in obesity.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Adipose Tissue ; Inflammation ; Obesity ; Innate Immunity ; Macrophages ; Eosinophils ; Innate Lymphoid Cells; Alternatively Activated Macrophages; Plasmacytoid Dendritic Cells; Obesity-induced Inflammation; Natural-killer-cells; Diet-induced Obesity; Insulin-resistance; Neutrophil Elastase; Energy-expenditure; Lymphoid Type-2; Visceral Fat
ISSN (print) / ISBN 1389-9155
e-ISSN 1573-2606
Quellenangaben Band: 19, Heft: 4, Seiten: 283-292 Artikelnummer: , Supplement: ,
Verlag Springer
Verlagsort Boston
Begutachtungsstatus Peer reviewed
Institut(e) Institute for Pancreatic Beta Cell Research (IPI)