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Chung, K.-J. ; Nati, M.* ; Chavakis, T. ; Chatzigeorgiou, A.*

Innate immune cells in the adipose tissue.

Rev. Endocr. Metab. Disord. 19, 283-292 (2018)
DOI Order publishers version
Open Access Green as soon as Postprint is submitted to ZB.
Immune cells are present in the adipose tissue (AT) and regulate its function. Under lean conditions, immune cells predominantly of type 2 immunity, including eosinophils, M2-like anti-inflammatory macrophages and innate lymphoid cells 2, contribute to the maintenance of metabolic homeostasis within the AT. In the course of obesity, pro-inflammatory immune cells, such as M1-like macrophages, prevail in the AT. Inflammation in the obese AT is associated with the development of metabolic complications such as insulin resistance, type 2 diabetes and cardiovascular disease. Thus, the immune cell-adipocyte crosstalk in the AT is an important regulator of AT function and systemic metabolism. We discuss herein this crosstalk with a special focus on the role of innate immune cells in AT inflammation and metabolic homeostasis in obesity.
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Publication type Article: Journal article
Document type Review
Keywords Adipose Tissue ; Inflammation ; Obesity ; Innate Immunity ; Macrophages ; Eosinophils ; Innate Lymphoid Cells; Alternatively Activated Macrophages; Plasmacytoid Dendritic Cells; Obesity-induced Inflammation; Natural-killer-cells; Diet-induced Obesity; Insulin-resistance; Neutrophil Elastase; Energy-expenditure; Lymphoid Type-2; Visceral Fat
ISSN (print) / ISBN 1389-9155
e-ISSN 1573-2606
Quellenangaben Volume: 19, Issue: 4, Pages: 283-292 Article Number: , Supplement: ,
Publisher Springer
Publishing Place Boston
Reviewing status Peer reviewed
Institute(s) Institute for Pancreatic Beta Cell Research (IPI)