Open Access Green as soon as Postprint is submitted to ZB.
Innate immune cells in the adipose tissue.
Rev. Endocr. Metab. Disord. 19, 283-292 (2018)
Immune cells are present in the adipose tissue (AT) and regulate its function. Under lean conditions, immune cells predominantly of type 2 immunity, including eosinophils, M2-like anti-inflammatory macrophages and innate lymphoid cells 2, contribute to the maintenance of metabolic homeostasis within the AT. In the course of obesity, pro-inflammatory immune cells, such as M1-like macrophages, prevail in the AT. Inflammation in the obese AT is associated with the development of metabolic complications such as insulin resistance, type 2 diabetes and cardiovascular disease. Thus, the immune cell-adipocyte crosstalk in the AT is an important regulator of AT function and systemic metabolism. We discuss herein this crosstalk with a special focus on the role of innate immune cells in AT inflammation and metabolic homeostasis in obesity.
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Publication type Article: Journal article
Document type Review
Keywords Adipose Tissue ; Inflammation ; Obesity ; Innate Immunity ; Macrophages ; Eosinophils ; Innate Lymphoid Cells; Alternatively Activated Macrophages; Plasmacytoid Dendritic Cells; Obesity-induced Inflammation; Natural-killer-cells; Diet-induced Obesity; Insulin-resistance; Neutrophil Elastase; Energy-expenditure; Lymphoid Type-2; Visceral Fat
ISSN (print) / ISBN 1389-9155
Quellenangaben Volume: 19, Issue: 4, Pages: 283-292
Publishing Place Boston
Reviewing status Peer reviewed
Institute(s) Institute for Pancreatic Beta Cell Research (IPI)