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Straube, C.* ; Antoni, S.* ; Gempt, J.* ; Zimmer, C.* ; Meyer, B.* ; Schlegel, J.* ; Schmidt-Graf, F.* ; Combs, S.E.

Re-irradiation in elderly patients with glioblastoma: A single institution experience.

J. Neuro-Oncol. 142, 327-335 (2019)
Publ. Version/Full Text DOI
Open Access Green as soon as Postprint is submitted to ZB.
BackgroundRe-Irradiation (Re-RT) is an established treatment option for young patients with recurrent glioblastoma (GBM). Multiple reports show a low risk of side-effects as well as a good efficacy resulting in median survival times ranging from 5 to 18 months. Elderly patients, however, are underrepresented in reports about Re-RT. Even in the elderly, with concomitant radiochemotherapy and adjuvant chemotherapy, progression-free survival times now are approaching 6months or even longer.MethodsWe report on 25 consecutive patients with at least 65years of age treated with Re-RT for recurrent GBM. We analyzed the patient's files for the treatment regimens, side-effects and survival times. Survival times, as well as hazards, were calculated by the Kaplan Meier method as well as Cox-regression method, respectively.ResultsThe median overall survival was 6.9months, treatment was well tolerated with only minor side effects. Use of systemic treatments as well as the length of the interval between 1st -line radiotherapy and re-irradiation were associated with a favorable prognosis. The latter remained significant after multivariate analysis.ConclusionRe-RT of elderly GBM patients should not be withheld based purely on age since the treatment is safe and results in comparable survival times to younger patients. When counseling elderly patients with recurrent GBM, especially the length of the interval since 1st line radiotherapy should be considered as a prognostic factor and an additional systemic treatment option should be considered.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Glioblastoma ; Elderly ; Re-irradiation ; Recurrent Glioblastoma ; Overall Survival; Radiation Plus Temozolomide; Stereotactic Reirradiation; Prognostic Score; Patients Older; Radiotherapy; Validation; Therapy; Gliomas
ISSN (print) / ISBN 0167-594X
e-ISSN 1573-7373
Quellenangaben Volume: 142, Issue: 2, Pages: 327-335 Article Number: , Supplement: ,
Publisher Springer
Publishing Place 233 Spring St, New York, Ny 10013 Usa
Reviewing status Peer reviewed