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Lämmermann, I.* ; Terlecki-Zaniewicz, L.* ; Weinmüllner, R.* ; Schosserer, M.* ; Dellago, H.* ; de Matos Branco, A.D.* ; Autheried, D.* ; Sevcnikar, B.* ; Kleissl, L.* ; Berlin, I.* ; Morizot, F.* ; Lejeune, F.* ; Fuzzati, N.* ; Forestier, S.* ; Toribio, A.* ; Tromeur, A.* ; Weinberg, L.* ; Almaraz, J.C.H. ; Scheideler, M. ; Rietveld, M.* ; El Ghalbzouri, A.* ; Tschachler, E.* ; Gruber, F.* ; Grillari, J.*

Blocking negative effects of senescence in human skin fibroblasts with a plant extract.

npj Aging Mech. Dis. 4:4 (2018)
Publ. Version/Full Text Research data DOI
Open Access Gold
Creative Commons Lizenzvertrag
There is increasing evidence that senescent cells are a driving force behind many age-related pathologies and that their selective elimination increases the life- and healthspan of mice. Senescent cells negatively affect their surrounding tissue by losing their cell specific functionality and by secreting a pro-tumorigenic and pro-inflammatory mixture of growth hormones, chemokines, cytokines and proteases, termed the senescence-associated secretory phenotype (SASP). Here we identified an extract from the plant subsp. , which exhibited weak senolytic activity, delayed the acquisition of a senescent phenotype and induced a papillary phenotype with improved functionality in human dermal fibroblasts. When administered to stress-induced premature senescent fibroblasts, this extract changed their global mRNA expression profile and particularly reduced the expression of various SASP components, thereby ameliorating the negative influence on nearby cells. Thus, the investigated plant extract represents a promising possibility to block age-related loss of tissue functionality.
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Publication type Article: Journal article
Document type Scientific Article
ISSN (print) / ISBN 2056-3973
e-ISSN 2056-3973
Quellenangaben Volume: 4 Issue: , Pages: , Article Number: 4 Supplement: ,
Publisher Nature Publishing Group
Publishing Place London [u.a.]
Reviewing status Peer reviewed