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de Sousa-Pereira, P. ; Abrantes, J.* ; Bauernfried, S.* ; Pierini, V.* ; Esteves, P.J.* ; Keppler, O.T. ; Pizzato, M.* ; Hornung, V.* ; Fackler, O.T.* ; Baldauf, H.-M.

The antiviral activity of rodent and lagomorph SERINC3 and SERINC5 is counteracted by known viral antagonists.

J. Gen. Virol. 100, 278-288 (2019)
Verlagsversion DOI
A first step towards the development of a human immunodeficiency virus (HIV) animal model has been the identification and surmounting of species-specific barriers encountered by HIV along its replication cycle in cells from small animals. Serine incorporator proteins 3 (SERINC3) and 5 (SERINC5) were recently identified as restriction factors that reduce HIV-1 infectivity. Here, we compared the antiviral activity of SERINC3 and SERINC5 among mice, rats and rabbits, and their susceptibility to viral counteraction to their human counterparts. In the absence of viral antagonists, rodent and lagomorph SERINC3 and SERINC5 displayed anti-HIV activity in a similar range to human controls. Vesicular stomatitis virus G protein (VSV-G) pseudotyped virions were considerably less sensitive to restriction by all SERINC3/5 orthologs. Interestingly, HIV-1 Nef, murine leukemia virus (MLV) GlycoGag and equine infectious anemia virus (EIAV) S2 counteracted the antiviral activity of all SERINC3/5 orthologs with similar efficiency. Our results demonstrate that the antiviral activity of SERINC3/5 proteins is conserved in rodents and rabbits, and can be overcome by all three previously reported viral antagonists.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Hiv-1 ; Restriction Factor ; Serinc ; Species-specific Antagonism
ISSN (print) / ISBN 0022-1317
e-ISSN 1465-2099
Quellenangaben Band: 100, Heft: 2, Seiten: 278-288 Artikelnummer: , Supplement: ,
Verlag Society for General Microbiology
Begutachtungsstatus Peer reviewed