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Niu, L.* ; Geyer, P.E.* ; Wewer Albrechtsen, N.J.* ; Gluud, L.L.* ; Santos, A.* ; Doll, S.* ; Treit, P.V.* ; Holst, J.J.* ; Knop, F.K.* ; Vilsbøll, T.* ; Junker, A.* ; Sachs, S. ; Stemmer, K. ; Müller, T.D. ; Tschöp, M.H. ; Hofmann, S.M. ; Mann, M.*

Plasma proteome profiling discovers novel proteins associated with non-alcoholic fatty liver disease.

Mol. Syst. Biol. 15:e8793 (2019)
Publ. Version/Full Text DOI
Open Access Gold
Creative Commons Lizenzvertrag
Non-alcoholic fatty liver disease (NAFLD) affects 25% of the population and can progress to cirrhosis with limited treatment options. As the liver secretes most of the blood plasma proteins, liver disease may affect the plasma proteome. Plasma proteome profiling of 48 patients with and without cirrhosis or NAFLD revealed six statistically significantly changing proteins (ALDOB, APOM, LGALS3BP, PIGR, VTN, and AFM), two of which are already linked to liver disease. Polymeric immunoglobulin receptor (PICR) was significantly elevated in both cohorts by 170% in NAFLD and 298% in cirrhosis and was further validated in mouse models. Furthermore, a global correlation map of clinical and proteomic data strongly associated DPP4, ANPEP, TGFBI, PIGR, and APOE with NAFLD and cirrhosis. The prominent diabetic drug target DPP4 is an aminopeptidase like ANPEP, ENPEP, and LAP3, all of which are up-regulated in the human or mouse data. Furthermore, ANPEP and TGFBI have potential roles in extracellular matrix remodeling in fibrosis. Thus, plasma proteome profiling can identify potential biomarkers and drug targets in liver disease.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Biomarker Discovery ; Mass Spectrometry ; Nafld ; Nash ; Plasma Proteome Profiling; Dipeptidyl Peptidase-4; Biomarker Discovery; Insulin-resistance; Fibrosis; Steatohepatitis; Galectin-3; Nash; Sitagliptin; Cirrhosis; Obesity
ISSN (print) / ISBN 1744-4292
e-ISSN 1744-4292
Quellenangaben Volume: 15, Issue: 3, Pages: , Article Number: e8793 Supplement: ,
Publisher EMBO Press
Publishing Place 111 River St, Hoboken 07030-5774, Nj Usa
Reviewing status Peer reviewed