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Energy metabolism in cachexia.

EMBO Rep. 20:e47258 (2019)
Verlagsversion Preprint DOI
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Cachexia is a wasting disorder that accompanies many chronic diseases including cancer and results from an imbalance of energy requirements and energy uptake. In cancer cachexia, tumor-secreted factors and/or tumor-host interactions cause this imbalance, leading to loss of adipose tissue and skeletal and cardiac muscle, which weakens the body. In this review, we discuss how energy enters the body and is utilized by the different organs, including the gut, liver, adipose tissue, and muscle, and how these organs contribute to the energy wasting observed in cachexia. We also discuss futile cycles both between the organs and within the cells, which are often used to fine-tune energy supply under physiologic conditions. Ultimately, understanding the complex interplay of pathologic energy-wasting circuits in cachexia can bring us closer to identifying effective treatment strategies for this devastating wasting disease.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Adipose Tissue ; Cachexia ; Inflammation ; Liver ; Skeletal Muscle; Brown-adipose-tissue; Acute-phase Response; Skeletal-muscle; Cancer Cachexia; Cachectic Patients; Lipid-metabolism; Weight-loss; Insulin Sensitivity; Pancreatic-cancer; Elderly-patients
ISSN (print) / ISBN 1469-221X
e-ISSN 1469-3178
Zeitschrift EMBO Reports
Quellenangaben Band: 20, Heft: 3, Seiten: , Artikelnummer: e47258 Supplement: ,
Verlag EMBO Press
Verlagsort 111 River St, Hoboken 07030-5774, Nj Usa
Begutachtungsstatus Peer reviewed