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Sales, A.H.A.* ; Bette, S.* ; Barz, M.* ; Huber, T.* ; Wiestler, B.* ; Ryang, Y.M.* ; Schmidt-Graf, F.* ; Liesche, F.* ; Combs, S.E. ; Meyer, B.* ; Gempt, J.*

Role of postoperative tumor volume in patients with MGMT-unmethylated glioblastoma.

J. Neuro-Oncol. 142, 529-536 (2019)
Verlagsversion DOI
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
PurposeThe aim of this study is to investigate the association between postoperative tumor volume and overall survival (OS) of O-6-methylguanine DNA methyltransferase (MGMT)-unmethylated glioblastoma patients.MethodsOne hundred-twenty-six patients with MGMT-unmethylated glioblastoma who were treated either with surgical resection or needle biopsy between 2006 and 2015 were included in this retrospective cohort. Pre- and postcontrast T1 weighted images were evaluated in order to determine pre- and postoperative contrast-enhancing tumor volumes (CE-TV). Cox regression models adjusted for other significant prognostic factors were used to investigate the association between postoperative tumor volume and survival.ResultsComplete resection of CE-TV was significantly associated with longer OS in the univariate analysis (HR 0.61; 95% CI 0.40-0.94; p=0.02). However, this fact could not be confirmed after adjusting the model for other relevant prognostic factors (HR 1.01; 95% CI 0.65-1.55; p=0.962). Postoperative CE-TV was significantly associated with survival in both univariate (HR: 1.04; 95% CI 1.025-1.055; p<0.001) and multivariate analyses (HR: 1.027; 95% CI 1.005-1.049; p=0.014).ConclusionsAlthough complete resection of tumor tissue was not significantly associated with longer OS in MGMT-unmethylated GBM patients, maximum safe resection should always be attempted, since postoperative tumor volume is strongly associated with OS.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Mgmt-methylation ; Glioblastoma ; Gross-total Resection ; Surgery; Gross Total Resection; Recurrent Glioblastoma; Promoter Methylation; Improved Survival; Prognostic Value; Temozolomide; Extent; Benefit; Surgery
ISSN (print) / ISBN 0167-594X
e-ISSN 1573-7373
Quellenangaben Band: 142, Heft: 3, Seiten: 529-536 Artikelnummer: , Supplement: ,
Verlag Springer
Verlagsort 233 Spring St, New York, Ny 10013 Usa
Begutachtungsstatus Peer reviewed