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Förster, K. ; Ertl-Wagner, B. ; Ehrhardt, H.* ; Busen, H. ; Sass, S. ; Pomschar, A.* ; Naehrlich, L.* ; Schulze, A.* ; Flemmer, A.W.* ; Hübener, C.* ; Eickelberg, O. ; Theis, F.J. ; Dietrich, O.* ; Hilgendorff, A.

Altered relaxation times in MRI indicate bronchopulmonary dysplasia.

Thorax 75, 184-187 (2020)
Verlagsversion Postprint DOI
Open Access Green
We developed a MRI protocol using transverse (T2) and longitudinal (T1) mapping sequences to characterise lung structural changes in preterm infants with bronchopulmonary dysplasia (BPD). We prospectively enrolled 61 infants to perform 3-Tesla MRI of the lung in quiet sleep. Statistical analysis was performed using logistic Group Lasso regression and logistic regression. Increased lung T2 relaxation time and decreased lung T1 relaxation time indicated BPD yielding an area under the curve (AUC) of 0.80. Results were confirmed in an independent study cohort (AUC 0.75) and mirrored by lung function testing, indicating the high potential for MRI in future BPD diagnostics.
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icb_biostatistics icb_statcon
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Paediatric Lung Disaese; Magnetic-resonance; Inflammation; Injury
ISSN (print) / ISBN 0040-6376
e-ISSN 1468-3296
Zeitschrift Thorax
Quellenangaben Band: 75, Heft: 2, Seiten: 184-187 Artikelnummer: , Supplement: ,
Verlag BMJ Publishing Group
Verlagsort British Med Assoc House, Tavistock Square, London Wc1h 9jr, England
Begutachtungsstatus