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Altered relaxation times in MRI indicate bronchopulmonary dysplasia.

Thorax, accepted (2019)
Postprint DOI
Open Access Green
as soon as is submitted to ZB.
We developed a MRI protocol using transverse (T2) and longitudinal (T1) mapping sequences to characterise lung structural changes in preterm infants with bronchopulmonary dysplasia (BPD). We prospectively enrolled 61 infants to perform 3-Tesla MRI of the lung in quiet sleep. Statistical analysis was performed using logistic Group Lasso regression and logistic regression. Increased lung T2 relaxation time and decreased lung T1 relaxation time indicated BPD yielding an area under the curve (AUC) of 0.80. Results were confirmed in an independent study cohort (AUC 0.75) and mirrored by lung function testing, indicating the high potential for MRI in future BPD diagnostics. Trial registration: DRKS00004600.
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icb_biostatistics icb_statcon
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Publication type Article: Journal article
Document type Scientific Article
Keywords Paediatric Lung Disaese
Reviewing status