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A chromatin-based signalling mechanism directs the switch from mutagenic to error-free repair of DNA double strand breaks.
Mol. Cell. Oncol. 6:1605820 (2019)
Mutations caused by DNA damage are a main driver of cancer. We discovered that recognition of newly synthesised histone H4 directs breast cancer type 1 susceptibility protein (BRCA1) to post-replicative chromatin. The switch from mutagenic to error-free DNA double strand break repair by homologous recombination is therefore controlled by chromatin.
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Publication type Article: Journal article
Document type Other: Opinion
Keywords 53bp1 ; Bard1 ; Brca1 ; Dna Double Strand Break Repair ; Homologous Recombination
Journal Molecular & Cellular Oncology
Quellenangaben Volume: 6, Issue: 4, Article Number: 1605820
Publisher Taylor & Francis
Reviewing status Peer reviewed
Institute(s) Institute of Functional Epigenetics (IFE)