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Association of dietary intake of milk and dairy products with blood concentrations of insulin-like growth factor 1 (IGF-1) in Bavarian adults.
Eur. J. Nutr. 59, 1413-1420 (2020)
Purpose Circulating IGF-1 concentrations have been associated with higher cancer risk, particularly prostate, breast and colorectal cancer. There is evidence from observational and intervention studies that milk and dairy products intake is associated with higher IGF-1 concentrations, but results were not always consistent. The purpose of this study was to examine the relationship between dairy intake and circulating IGF-1 concentrations in participants of the Second Bavarian Food Consumption Survey, thereby providing data for a German population for the first time. Methods In this cross-sectional study of 526 men and women aged 18-80 years, in contrast to most previous investigations, dietary intake was assessed with a more detailed instrument than food frequency questionnaires (FFQs), i.e., by three 24-h dietary recalls conducted on random days close in time to the blood collection. Circulating IGF-1 concentrations were measured in blood samples. Multivariable linear regression models were used to examine the association of dairy intake with IGF-1 concentrations. Results Each 400 g increment in daily dairy intake was associated with 16.8 mu g/L (95% CI 6.9, 26.7) higher IGF-1 concentrations. Each 200 g increment in milk per day was associated with 10.0 mu g/L (95% CI 4.2, 15.8) higher IGF-1. In contrast, we observed no association between cheese or yogurt intake and IGF-1 concentrations. Conclusions Our findings are in line with most previous investigations and support the hypothesis that dairy and milk intake are associated with higher IGF-1 concentrations.
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Publication type Article: Journal article
Document type Scientific Article
Keywords 24-h Dietary Recall ; Dairy ; Igf-1 ; Milk; Factor Binding Protein-3; Cross-sectional Analysis; Life-style Factors; Factor-i; Circulating Levels; Colorectal-cancer; Igfbp-3; Risk; Healthy; Meat
ISSN (print) / ISBN 1436-6207
Journal European Journal of Nutrition
Quellenangaben Volume: 59, Issue: 4, Pages: 1413-1420
Publishing Place Heidelberg
Reviewing status Peer reviewed