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Aminzadeh-Gohari, S.* ; Weber, D.D.* ; Vidali, S. ; Catalano, L.* ; Kofler, B.* ; Feichtinger, R.G.*

From old to new - Repurposing drugs to target mitochondrial energy metabolism in cancer.

Semin. Cell Dev. Biol. 98, 211-223 (2020)
Verlagsversion DOI
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
Although we have entered the era of personalized medicine and tailored therapies, drugs that target a large variety of cancers regardless of individual patient differences would be a major advance nonetheless. This review article summarizes current concepts and therapeutic opportunities in the area of targeting aerobic mitochondrial energy metabolism in cancer. Old drugs previously used for diseases other than cancer, such as antibiotics and antidiabetics, have the potential to inhibit the growth of various tumor entities. Many drugs are reported to influence mitochondrial metabolism. However, here we consider only those drugs which predominantly inhibit oxidative phosphorylation.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Aerobic Mitochondrial Energy Metabolism ; Oxidative Phosphorylation Complex ; Antibiotic ; Antidiabetic ; Chemotherapeutic; Induced Oxidative Stress; Chronic Myeloid-leukemia; Cell-cycle Arrest; Complex-i; Lung-cancer; Stem-cells; Inhibits Proliferation; Antibiotic Exposure; Somatic Mutations; Dna Mutations
ISSN (print) / ISBN 1084-9521
e-ISSN 1096-3634
Quellenangaben Band: 98, Heft: , Seiten: 211-223 Artikelnummer: , Supplement: ,
Verlag Academic Press
Verlagsort London
Begutachtungsstatus Peer reviewed