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Kimm, M.A.* ; Gross, C.* ; Déan-Ben, X.L.* ; Ron, A. ; Rummeny, E.J.* ; Lin, H.-C. ; Höltke, C.* ; Razansky, D. ; Wildgruber, M.*

Optoacoustic properties of Doxorubicin - A pilot study.

PLoS ONE 14:e0217576 (2019)
Verlagsversion Forschungsdaten DOI
Open Access Gold
Creative Commons Lizenzvertrag
Doxorubicin (DOX) is a widely used chemotherapeutic anticancer drug. Its intrinsic fluorescence properties enable investigation of tumor response, drug distribution and metabolism. First phantom studies in vitro showed optoacoustic property of DOX. We therefore aimed to further investigate the optoacoustic properties of DOX in biological tissue in order to explore its potential as theranostic agent. We analysed doxorubicin hydrochloride (Dox center dot HCl) and liposomal encapsulated doxorubicin hydrochloride (Dox center dot Lipo), two common drugs for anticancer treatment in clinical medicine. Optoacoustic measurements revealed a strong signal of both doxorubicin substrates at 488 nm excitation wavelength. Post mortem analysis of intra-tumoral injections of DOX revealed a detectable optoacoustic signal even at three days after the injection. We thereby demonstrate the general feasibility of doxorubicin detection in biological tissue by means of optoacoustic tomography, which could be applied for high resolution imaging at mesoscopic depths dictated by effective penetration of visible light into the biological tissues.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Tomography Msot; Tumor; Model; Quantification; Chemotherapy; Liposomes; Dynamics; Cancer; Tissue; Light
ISSN (print) / ISBN 1932-6203
Zeitschrift PLoS ONE
Quellenangaben Band: 14, Heft: 5, Seiten: , Artikelnummer: e0217576 Supplement: ,
Verlag Public Library of Science (PLoS)
Verlagsort Lawrence, Kan.
Begutachtungsstatus Peer reviewed