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Ntini, E.* ; Marsico, A.

Functional impacts of non-coding RNA processing on enhancer activity and target gene expression.

J. Mol. Cell Biol. 11, 868-879 (2019)
Publ. Version/Full Text Postprint DOI
Open Access Green
Creative Commons Lizenzvertrag
Tight regulation of gene expression is orchestrated by enhancers. Through recent research advancements, it is becoming clear that enhancers are not solely distal regulatory elements harboring transcription factor binding sites and decorated with specific histonemarks, but they rather display signatures of active transcription, showing distinct degrees of transcription unit organization. Thereby, a substantial fraction of enhancers give rise to different species of non-coding RNA transcripts with an unprecedented range of potential functions. In this review, we bring together data from recent studies indicating that non-coding RNA transcription from active enhancers, as well as enhancer-produced long non-coding RNA transcripts, may modulate or define the functional regulatory potential of the cognate enhancer. In addition, we summarize supporting evidence that RNA processing of the enhancer-associated long non-coding RNA transcripts may constitute an additional layer of regulation of enhancer activity, which contributes to the control and final outcome of enhancer-targeted gene expression.
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Publication type Article: Journal article
Document type Review
Keywords Transcription ; Enhancer ; Rna Processing ; Cotranscriptional Rna Splicing ; Chromatin ; Long Non-coding Rna (lncrna); Messenger-rna; Polymerase-ii; Unified Architecture; Mammalian Promoters; Binding Proteins; X-inactivation; Maps Reveal; Gc Content; Chromatin; Transcription
ISSN (print) / ISBN 1674-2788
e-ISSN 1673-520X
Quellenangaben Volume: 11, Issue: 10, Pages: 868-879 Article Number: , Supplement: ,
Publisher Oxford University Press
Publishing Place Great Clarendon St, Oxford Ox2 6dp, England
Reviewing status