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Rabus, H.* ; Gargioni, E.* ; Li, W.B. ; Nettelbeck, H.* ; Villagrasa, C.*

Determining dose enhancement factors of high-Z nanoparticles from simulations where lateral secondary particle disequilibrium exists.

Phys. Med. Biol. 64:155016 (2019)
Publ. Version/Full Text Postprint DOI
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
Nanoparticles (NPs) containing high atomic number (high-Z) materials have been shown to enhance the radiobiological effectiveness of ionizing radiation. This effect is often attributed to an enhancement of the absorbed dose in the vicinity of the NPs, based on Monte Carlo simulations that show a significant local enhancement of the energy deposition on the microscopic scale. The results of such simulations may be significantly biased and lead to a severe overestimation of the dose enhancement if the condition of secondary particle equilibrium is not met in the simulation setup. This current work shows an approach to estimate a 'realistic' dose enhancement from the results of such biased simulations which is based on published photon interaction data and provides a way for correcting biased results.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Dose Enhancement ; Gold Nanoparticles ; High-z Nanoparticles ; Monte Carlo Simulation ; Secondary Electron Equilibrium; Monte-carlo-simulation; Gold Nanoparticles; Radiation; Radiotherapy; Brachytherapy
ISSN (print) / ISBN 0031-9155
e-ISSN 1361-6560
Quellenangaben Volume: 64, Issue: 15, Pages: , Article Number: 155016 Supplement: ,
Publisher Institute of Physics Publishing (IOP)
Publishing Place Bristol
Reviewing status Peer reviewed