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Chen, W.* ; Cheng, C.A.* ; Cosco, E. ; Ramakrishnan, A. ; Lingg, J.G.P.* ; Bruns, O.T. ; Zink, J.I.* ; Sletten, E.M.*

Shortwave infrared imaging with J-aggregates stabilized in hollow mesoporous silica nanoparticles.

J. Am. Chem. Soc. 141, 12475-12480 (2019)
DOI
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Tissue is translucent to shortwave infrared (SWIR) light, rendering optical imaging superior in this region. However, the widespread use of optical SWIR imaging has been limited, in part, by the lack of bright, biocompatible contrast agents that absorb and emit light above 1000 nm. J-Aggregation offers a means to transform stable, near-infrared (NJR) fluorophores into red-shifted SWIR contrast agents. Here we demonstrate that J-aggregates of NIR fluorophore IR-140 can be prepared inside hollow mesoporous silica nanoparticles (HMSNs) to result in nanomaterials that absorb and emit SWIR light. The J-aggregates inside PEGylated HMSNs are stable for multiple weeks in buffer and enable high resolution imaging in vivo with 980 nm excitation.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Drug-delivery; Quantum Dots; Fluorescence; Nanomachines; Nanospheres; Absorption; Principles; Stimuli; Design
ISSN (print) / ISBN 0002-7863
e-ISSN 1520-5126
Quellenangaben Band: 141, Heft: 32, Seiten: 12475-12480 Artikelnummer: , Supplement: ,
Verlag American Chemical Society (ACS)
Verlagsort 1155 16th St, Nw, Washington, Dc 20036 Usa
Begutachtungsstatus Peer reviewed
Institut(e) Helmholtz Pioneer Campus (HPC)