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Berezhnoi, A. ; Aguirre Bueno, J. ; Hindelang, B.* ; Garzorz-Stark, N.* ; Omar, M. ; Darsow, U.* ; Eyerich, K.* ; Ntziachristos, V.

Optical features of human skin revealed by optoacoustic mesoscopy in the visible and short-wave infrared regions.

Opt. Lett. 44, 4119-4122 (2019)
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Detailed assessment of skin conditions or the efficacy of skin treatments could greatly benefit from noninvasively assessing the distribution of cutaneous and subcutaneous structures and biomolecules. We considered ultrawideband raster scan optoacoustic mesoscopy with an extended wavelength range from visible to short-wave infrared and observed previously unseen high-resolution images of lipids colocalized with water, melanin, and hemoglobin distribution in human skin. Based on this contrast, the technique resolves subcutaneous fat, the pilosebaceous unit with complete hair strand and bulb, dermal microvasculature, and epidermal structures. We further visualize melanoidins that form via the Maillard reaction in the ultrathin stratum corneum layer, analyze their absorption spectrum, and separate them from the melanin layer. The suggested method may allow novel interrogation of skin conditions, possibly impacting diagnostics and medical and cosmetic treatments.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Adipose-tissue
ISSN (print) / ISBN 0146-9592
e-ISSN 1539-4794
Zeitschrift Optics Letters
Quellenangaben Band: 44, Heft: 17, Seiten: 4119-4122 Artikelnummer: , Supplement: ,
Verlag Optical Society of America (OSA)
Verlagsort 2010 Massachusetts Ave Nw, Washington, Dc 20036 Usa
Begutachtungsstatus Peer reviewed