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Kuchenbaecker, K.* ; Telkar, N.* ; Reiker, T.* ; Walters, R.G.* ; Lin, K.* ; Eriksson, A.* ; Gurdasani, D.* ; Gilly, A. ; Southam, L. ; Tsafantakis, E.* ; Karaleftheri, M.* ; Seeley, J.* ; Kamali, A.* ; Asiki, G.* ; Millwood, I.Y.* ; Holmes, M.* ; Du, H.* ; Guo, Y.* ; Kumari, M.* ; Dedoussis, G.* ; Li, L.* ; Chen, Z.* ; Sandhu, M.S.* ; Zeggini, E.

The transferability of lipid loci across African, Asian and European cohorts.

Nat. Commun. 10:4330 (2019)
Publ. Version/Full Text Research data DOI
Open Access Gold
Creative Commons Lizenzvertrag
Most genome-wide association studies are based on samples of European descent. We assess whether the genetic determinants of blood lipids, a major cardiovascular risk factor, are shared across populations. Genetic correlations for lipids between European-ancestry and Asian cohorts are not significantly different from 1. A genetic risk score based on LDL-cholesterol-associated loci has consistent effects on serum levels in samples from the UK, Uganda and Greece (r= 0.23-0.28, p < 1.9 x 10(-14)). Overall, there is evidence of reproducibility for -75% of the major lipid loci from European discovery studies, except triglyceride loci in the Ugandan samples (10% of loci). Individual transferable loci are identified using trans-ethnic colocalization. Ten of fourteen loci not transferable to the Ugandan population have pleiotropic associations with BMI in Europeans; none of the transferable loci do. The non-transferable loci might affect lipids by modifying food intake in environments rich in certain nutrients, which suggests a potential role for gene-environment interactions.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Genetic Associations; Wide Association; Blood-lipids; Mixed-model; Variants; Genomics; Biobank; Disease; Traits; Health
ISSN (print) / ISBN 2041-1723
e-ISSN 2041-1723
Quellenangaben Volume: 10, Issue: 1, Pages: , Article Number: 4330 Supplement: ,
Publisher Nature Publishing Group
Publishing Place London
Reviewing status Peer reviewed
Institute(s) Institute of Translational Genomics (ITG)