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Digital biomarkers: Importance of patient stratification for re-irradiation of glioma patients - Review of latest developments regarding scoring assessment.

Phys. Med. 67, 20-26 (2019)
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Purpose: To review scoring assessments in re-irradiation of high-grade glioma (HGG) patients and how to use scoring for patient stratification. The next aim was to investigate the different approaches employed by the scoring systems and the way they can be applied to build homogeneous patient groups for a reliable prognosis.Methods: We searched the Medline/Pubmed and Web of science databases for relevant articles regarding scores for re-irradiation of recurrent HGG. All references were divided into the following groups: novel score establishment (n = 5), score validation (n = 6), not relevant to this evaluation (n = 26).Results: We identified five scoring systems. Two are modifications of an already existing score. Calculations differ immensely from easy point addition to a more complex formula with including three up to 10 individual parameters. Six validation articles were found for three of the scores; one was validated four times. Two scores were never validated.Conclusion: For recurrent HGG, the clinical situation remains demanding. Due to the heterogeneity of data at reirradiation, patient stratification is important. Several scoring systems have been developed to predict prognosis. As a digital biomarker, scores are of high value regarding quick patient assessment and therapy decision making. For the next generation of digital biomarkers, easy calculation, and inclusion of easily available parameters are crucial.
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Publication type Article: Journal article
Document type Scientific Article
Keywords High-grade Glioma ; Re-irradiation ; Score ; Patient Stratification ; Scoring Assessment; Recurrent Glioblastoma-multiforme; High-grade Gliomas; Fractionated Stereotactic Reirradiation; Prognostic Score; Multicenter; Validation; Resection; Survival; Radiosurgery; Reoperation
ISSN (print) / ISBN 1120-1797
e-ISSN 1724-191X
Quellenangaben Volume: 67, Issue: , Pages: 20-26 Article Number: , Supplement: ,
Publisher Elsevier
Publishing Place The Boulevard, Langford Lane, Kidlington, Oxford Ox5 1gb, Oxon, England
Reviewing status Peer reviewed