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Ferroptose: Tod durch Eisenabhängige Lipidperoxidation.

BioSpektrum 25, 614-616 (2019)
DOI Verlagsversion bestellen
Ferroptosis is an oxidative form of necrotic cell death highly relevant for many degenerative diseases and cancer. Ferroptosis is marked by iron-dependent lipid peroxidation and is distinct from other cell death modalities. Glutathione peroxidase 4 is the key ferroptosis player as it efficiently controls lipid peroxidation. Transgenic mice and animal models of disease have shown which cells and tissues are prone to undergo ferroptosis. The discovery of novel ferroptosis inhibitors and inducers thus offers the great potential in the development of innovative drugs to treat yet incurable diseases.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
ISSN (print) / ISBN 0947-0867
e-ISSN 1868-6249
Zeitschrift BioSpektrum
Quellenangaben Band: 25, Heft: 6, Seiten: 614-616 Artikelnummer: , Supplement: ,
Verlag Springer
Begutachtungsstatus Peer reviewed